Integrated photonics has transformed optical technology, yet conventional on-chip waveguides remain constrained to planar geometries with limited design flexibility. At the same time, applications spanning chiral sensing, quantum optics, nonlinear optics, and lab-on-chip spectroscopy require more versatile waveguide platforms for strong light-matter interaction. In this issue, researchers introduce the concept of the twisted hollow-core light cage, a chiral on-chip waveguide platform with an air core fabricated via 3D nanoprinting. These sidewise-open structures leave the air core accessible to external species while their built-in twist imparts a strong chiral response, achieving twist rates and circular dichroism over two orders of magnitude higher than in twisted hollow-core fibers.