A CoCrFeNiTi high-entropy alloy coating was prepared on the surface of 316L stainless steel using laser cladding technology. The phase composition, microstructure, elemental distribution, nanoindentation characteristics, and wear resistance of the coating were investigated. The addition of Ti resulted in the formation of new body-centered cubic (BCC) phases in the alloy, enhancing the abrasion resistance and hardness of the coatings. The hardness of the CoCrFeNi coating increased significantly from 389 HV to 579 HV with the addition of Ti, corresponding to a 48.84% increase in Vickers hardness. This increase is attributed to the solid solution strengthening effect of Ti and the precipitation strengthening effect of the Laves phase. Wear coefficient curves indicated that the alloys with added Ti exhibited lower wear coefficients and higher wear resistance. The CoCrFeNiTi coating demonstrated reduced wear volume and wear rate compared to the CoCrFeNi coating. The wear mechanism of the CoCrFeNiTi high-entropy alloy coating involves abrasive wear accompanied by adhesive wear.