Aiming at the fragmentation dispersion characteristic of prefabricated fragment ammunition, fuze-warhead coordination was designed based on prefabricated fragment ammunition controlled by laser proximity fuze. Ideal warhead explosion height was obtained through formula deduction, Matlab software simulation and calculation of target damage at a equivalent area. Under this condition of the ideal explosion height, the laser fuze was designed through selecting appropriate laser beam detection field. Thus a optimal design of fuze-warhead coordination under specified conditions was completed. Results showed that: in the the range of 5 m of the missile dispersion, 60° pitch angle and 5 m × 3 m×3 m command vehicle target, effective fragment density is the biggest at the warhead explosion 4-6 m height. Detection probability and height of the laser proximity fuze are analyzed and calculated at the height interval of the detonating height, the optimal beam emission angle of laser fuze is from 17° to 30°. This design is of practical reference value for the application of the prefabricated fragment ammunition controlled by laser fuze.