Three different samples of Ti6Al4V, GH3536 and 316L stainless steel were prepared by laser selective melting process. The microstructure evolution and mechanical properties were studied by means of optical microscope (OM), scanning electron microscope (SEM), universal tensile testing machine and Vickers hardness tester. The results show that a large amount of needle-shaped marten site α′ phase is distributed inside Ti6Al4V, which is decomposed into α+β phase during the forming process to form a net basket structure. GH3536 has a strip shape in cross section and a fish scale shape in longitudinal section. Equiaxed crystals are distributed in 316L stainless steel. The average elongations of 316L stainless steel and GH3536 are 34.17% and 36.75%, respectively, which are 23.69% and 26.27% higher than that of Ti6Al4V. The tensile strength and yield strength of Ti6Al4V are 1 122.83 MPa and 853.17 MPa, which are better than GH3536 and 316L stainless steel. The tensile strength is increased by 51.63% and 74.81%, and the yield strength is increased by 159.85% and 54.37% respectively. The strength of the sample is higher than the national standard strength level of common forging, reaching the industrial use requirements, the comprehensive performance is better than the traditional manufacturing process, and the sample has better strong plastic matching under laser selective melting.