The effects of different amounts of zinc oxide on the antibacterial properties and process properties of soda-lime glass produced by high-temperature melting method were studied. The results showed that when the introduction of zinc oxide was higher than 3%, the antibacterial activity of the glass against Escherichia coli and Staphylococcus aureus reached more than 90%, and the introduction of zinc oxide reduced the surface tension and high temperature viscosity of the glass, increased the bubble discharge rate of the glass melt during the melting process, reduced the number of bubbles, and promoted the clarification of the glass melt, which was suitable for process production.