The polarization images contains more information from surface and superficial surface than traditional image, so it can be used to detect and evaluate the skin state by obtaining the polarization information of abnormal and normal skin areas. This project built a multi-waveband laser-illuminated skin polarization imaging system, and carried out laser polarization images experiments on normal skin, pigment deposition region and inflammation region under blue, green and red three-waveband laser illumination. The main results were as follows: 1) Under 488 nm blue light and 520 nm green light laser illumination, the polarization degree data of the pigment deposition region, the inflammation region and the normal skin area were significantly different; 2) Under 660 nm red laser illumination, there was a significant difference between the pigment deposition region and the normal skin area, but the data of the inflammatory region and the normal skin region were similar; 3) The polarization image information of the three-wavelength laser for the pigment deposition region is similar. The comprehensive analysis shows that the polarization image and polarization degree data of simulated skin under green laser illumination can easily distinguish the interface and difference between normal skin and pigment deposition and inflammatory skin area. The polarization images of the pigment deposition region are more similar, showing the same subcutaneous depth information. The polarization image of the inflammatory region has great difference, which is the polarization information of the skin at different depths.