In order to improve the image quality and variable range of focal length of liquid lenses, a double-interface liquid lens based on a combination structure is designed utilizing dielectrophoretic and hydraulic drive mechanisms, which mainly consists of a dielectrophoretic double-liquid lens and a PDMS membrane liquid lens. First, the liquid lens model is established with Comsol software, the surface profile changes of droplets and PDMS membrane under different voltages are studied, and the surface profile data of two surfaces are derived. Second, the aspherical expression is used to fit with Matlab software, and the interface profiles of droplets and PDMS membrane under different voltages and the corresponding aspherical coefficient are obtained. Finally, the corresponding double-interface combined liquid lens optical model is built with Zemax software, and the image plane is selected as the Gaussian image plane. The simulation and experimental data are compared and analyzed through the corresponding device’s fabrication and the preliminary experimental research. The results show that the variable focal length range of the designed double-interface liquid lens based on the combined structure of the simulation is consistent with that of the experiment. Additionally, the results show that the zoom ratio and the imaging resolution can reach 2.1254 and 101.5937 lp/mm, respectively. The double-interface liquid lens based on the combination structure has the advantages of a simple and compact structure, strong interface adjustability, and high resolution imaging.