The single pass orthogonal test was carried out for Ni204 by laser cladding technology. The geometry size and microstructure of the clad track were measured by laser confocal microscopy. The effects of different process parameters on the morphology and microstructure of the samples were analyzed by variance analysis. The results show that the power has the most significant influence on the melting width and depth. The influence of scanning speed on the melting height, the ratio of width and height and wetting angle was most significant. When the energy density is too small, the Ni204 alloy powder does not generate a molten pool on the substrate. The microstructure at the boundary of the molten pool is columnar crystal. In the molten pool, the grain growth time is short and recrystallization is not easy, and the molten pool is dendritic. Through analysis, the optimal process parameter groups were Lp＝750 W, Pfr＝0.8 r/min, Ss＝480 mm/min and Lp＝900 W, Pfr＝1 r/min, Ss＝480 mm/min which can ensure the horizontal and vertical overlap without reducing the cladding efficiency.