Objective: To observe the effect of ultrasound-guided tumescence anesthesia solution on postoperative pain of endovenous laser ablation of lower extremity varicose vein. Methods: 90 cases of patients with lower extremity varicose vein were divided randomly into study group and control group, 45 cases in each group, two groups were treated by endovenous laser ablation, study group was assisted by ultrasound-guided tumescence anesthesia solution, and control group was assisted by traditional epidural anesthesia. Clinical efficacy, nerve block, perioperative heart rate (HR) and mean arterial pressure (MAP), postoperative visual analogue score (VAS) and postoperative recovery of daily activities were compared between the two groups. Results: ①The total effective rate in the study group was 91.11%, higher than that in the control group (86.67%), but there was no statistically significant difference in clinical efficacy between the two groups (P>0.05).②The onset time of nerve block in the study group was shorter than that in the control group (P<0.05), and the score of nerve block in the study group at 5, 10 and 15 minutes was higher than that in the control group (P<0.05). There was no statistical difference in the success rate of nerve block between the two groups (P>0.05).③At the beginning of the operation and 15, 30 min after the operation, HR in the two groups was lower than that before the operation (P<0.05), and MAP was higher than that before the operation (P<0.05), but the differences in HR and MAP at different time points between the two groups were not statistically significant (P>0.05).④There was no statistically significant difference in VAS score at postoperative anesthesia recovery between the two groups, but VAS scores at 2, 4, 6, and 8 h after surgery in the study group were lower than those in the control group (P<0.05).⑤The recovery rates of daily activities in the study group at 1 d, 2 d and 3d after surgery were all higher than those in the control group (P<0.05). Conclusion: The use of tumescence anesthesia solution in the treatment of lower extremity varicose veins by intracavitary laser can alleviate postoperative pain better than traditional epidural block anesthesia.