The laser cladding technology was used to prepare GH4169 coating on the surface of as-rolled GH4169 alloy. The microstructure, precipitation phases, high temperature micro-hardness and high temperature wear properties of the coating were studied. Results show that there are no defects, such as pores and cracks in the coating, and it is mainly composed of Laves segregation phase, γ matrix phase and a small amount of MC and MN phases. The average micro-hardness of coating at room temperature is 273.6 HV (0.3 kg test force), and with the increase of the test temperature, its micro-hardness shows a downward trend at different temperatures. When the test temperature is 600 ℃, its micro-hardness decreases to 197.4 HV (0.3 kg test force), about 72% of that at room temperature. High temperature wear property results also show that the wear rate decreases with the increase of the test temperature. When the test temperature is 600 ℃, the wear rate of the sample is close to 25% of that of the room temperature tested sample. After the wear test, the micro-hardness of the samples, which test temperatures are not higher than 500 ℃, have no obvious change, while the room temperature micro-hardness of the coating with the test temperature of 600 ℃ is increased due to the precipitation of strengthening phase.