In order to improve the accuracy of numerical simulation of laser cladding repairing aero-engine variable-curvature failure blades and to identify errors in a timely and accurate manner, a method of loading area in the repair process based on dynamic boundary conditions is proposed. Firstly, a blade finite element model with a higher degree of restoration was established based on the variable-curvature failed blade to ensure that the model can reflect the true state of the variable-curvature failed blade during repair. Secondly, the proposed method was used to repair the variable-curvature failure by laser cladding. The thermal-stress field simulation calculation of the blade is used to extract real-time working condition data to realize the quantitative study of the influence of process parameters on the results. Finally, the influence of laser parameters and process parameters on the temperature field and stress field of the variable curvature blade is analyzed separately. Results show that when the values before and after the laser scanning speed increase proportionally, the difference between the melt pool temperature before and after the variable curvature blade is around 500 ℃. The appropriate cooling time between passes can greatly reduce the melt pool temperature of the variable curvature blade, but it has small impact on the stress field.