ObjectiveTo investigate the relationship between clinical characteristics and laboratory indicators with the 30-day mortality risk in patients with spontaneous intracerebral hemorrhage (ICH).MethodsA retrospective analysis was conducted on medical records of 363 ICH patients admitted to the neurology wards of two hospitals in Shanghai from December 2019 to December 2021. A total of 360 cases were included, with 310 in the survival group and 50 in the mortality group. Clinical features and laboratory indicators were collected, and univariate and multivariate Logistic regression analyses as well as ROC analysis were performed.ResultsThe 30-day mortality rate of ICH patients was 13.89%. The age, NIHSS score, and hemorrhage volume were significant factors correlated with the mortality risk. Among laboratory indicators, there were significant differences in red blood cell count, D-dimer, hemoglobin level, and random blood glucose between the surviving and deceased groups. Multivariate Logistic regression analysis revealed that NIHSS score (OR=1.163, 95%CI: 1.111-1.219, P<0.001) and FT3 level (OR=0.501, 95%CI: 0.273-0.919, P=0.026) were independent factors associated with 30-day mortality risk in ICH patients. ROC analysis indicated that the NIHSS model, 1/FT3 model, and composite model all had good predictive efficacy.ConclusionNIHSS score and FT3 level are important indicators for assessing the 30-day mortality risk in ICH patients, it may assist clinicians in better evaluating and managing the mortality risk in these patients.