Intra-channel four-wave mixing (IFWM) affects system performance in 160 Gb/s optical time division multiplexing (OTDM) communication systems. The effect of IFWM on the performance of a 160 Gb/s OTDM transmission system is analyzed. Strong dispersion management to suppress the detrimental effects of IFWM is theoretically presented and experimentally verified. The results show that amplitude fluctuation at "1" bit and ghost pulses at "0" bit are well suppressed by strong dispersion management in transmission link. The whole system performance is improved. Stable error-free (bit error rate less than 10-12) transmission over 107.6 km after more than 2 h is achieved without forward-error correction, and the power penalty is about 3.6 dB.