The effects of substrate thickness and scanning mode on the residual stress, microstructure, and tensile property of GH4169 alloy components after laser deposition repair (LDR) are investigated. The results show that the smaller the substrate thickness or the larger the deposition thickness is，the larger both the residual stress and the volume fraction of the interdendritic Laves phase are, in contrast, the smaller both the tensile strength and the percentage elongation after fracture at room temperature are. The experiment indicates that the short edge scanning mode is beneficial to improving the tensile property at room temperature of GH4169 alloy after LDR.