To defect detection of Printed Circuit Board (PCB) is an important in the detection domain of computer vision. In order to use reference method to detect photoelectric image of printed-circuit-board, we need to improve accuracy of image registration. The new registration method based on randomized Hough theory and affine transform in the geometric transformations is proposed. The efficiency of finding and finishing image registration has been induced. After the contradistinctive experiments for the detection of photoelectric image of PCB obtained in reality, the detection method proposed in this paper has obvious advantage in the aspects of increasing detection precision, reducing memory space and time.