Laser & Optoelectronics Progress, Volume. 59, Issue 12, 1200001(2022)

Label-Free Optical Imaging Technology

Shuqi Mu1,2, Dashan Dong1,2, and Kebin Shi1,2、*
Author Affiliations
  • 1State Key Laboratory of Artificial Microstructure and Mesoscopic Physics, School of Physics, Peking University, Beijing 100871, China
  • 2Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan 030006, Shanxi , China
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    Label-free optical imaging technology can perform long-term, noninvasive, high-resolution imaging on living cells owing to its noninvasive characteristics. This technology has promising applications in biomedical research and clinical diagnosis. Label-free imaging technologies can be categorized into specific imaging and nonspecific imaging. In this paper, we review the commonly used label-free imaging. Herein, the imaging principles, advantages and disadvantages, as well as the recent progresses of unmarked imaging are introduced in detail. Furthermore, the future development of the label-free imaging technology is prospected.


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    Shuqi Mu, Dashan Dong, Kebin Shi. Label-Free Optical Imaging Technology[J]. Laser & Optoelectronics Progress, 2022, 59(12): 1200001

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    Paper Information

    Category: Reviews

    Received: Nov. 1, 2021

    Accepted: Nov. 29, 2021

    Published Online: May. 23, 2022

    The Author Email: Shi Kebin (



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