This study explored the effect of varying the angle of attack of airfoil on the output performance of the valveless piezoelectric pump. It placed symmetrical and asymmetrical airfoils in the tube respectively， and designed valveless piezoelectric pumps with airfoil baffles at various angles of attack（0°，5°，10° and 15°）. Output performance tests were conducted on the piezoelectric pump. Additionally， flow field simulations using COMSOL software were performed to analyze the vortex structures and energy dissipation characteristics. The experimental results showed that the National Advisory Committee for Aeronautics （NACA） 0015 piezoelectric pump performs optimally at a 0° angle of attack， achieving a maximum flow rate of 235.56 ml/min. Under the same angle of attack， the performance of the piezoelectric pump with symmetrical airfoil baffles was better than that of the piezoelectric pump with asymmetrical airfoil baffles. As the angle of attack increased， the piezoelectric pump performance decreased. The simulation results indicated that the scale of the vortices around the airfoil baffle during the reverse flow was higher than that during the positive flow； under the same angle of attack， the vortices around the NACA63-412 airfoil were significantly denser and larger than those around the NACA0015 airfoil. Increasing the angle of attack led to vortex aggregation and intensity rise， accompanied by escalated energy dissipation. The study concludes that the angle of attack significantly affects the pump's performance， with larger angles exacerbating energy dissipation and reducing output. This research provides new insights and theoretical foundations for the design and optimization of high-performance valveless piezoelectric pumps.