In combination with characteristics of cavity spatial filter far-field alignment on SG-II-Up facility, a serial- parallel alignment control method based on combination of feed forward compensation and feedback regulation is presented by establishing coupling models between pinholes. The reference centers are stable and reliable extracted out by position predication and gray gradient extremum search. The feedback regulation quantity is determined by image Jacobian matrix for each pinhole. Regulation of previous pinhole is regarded as disturbance to the next one, and the feed forward compensation control quantity is calculated according to the established coupling model between pinholes. The serial- parallel alignment controls for multi- pinholes are implemented simultaneously by synthesizing the feedback and feed forward control quantities. Experimental results show that the reference center extraction accuracy reaches above 97%, collimating time reduces from 1 min to 30 s, and the collimating efficiency improves greatly.