This study investigates the surface morphology characteristics of TC4 titanium alloy material subjected to water jet-guided laser processing. Cutting tests were performed on 2 mm thick TC4 titanium alloy rolled plates using LCS305 water jet-guided laser processing equipment from Synova. The surface morphology of the cuts was examined using a CCD industrial microscope, scanning electron microscope, and optical profilometer. The experimental results show that the cross-section of TC4 titanium alloy processed by water jet-guided laser will produce transverse stripes, and the number of transverse stripes is the same as the scanning cycle of water jet-guided laser. The cutting surface of TC4 titanium alloy can be divided into four kinds of regions according to the different characteristics, namely: uplift zone, depression zone, crushed stone zone and ripple zone. The morphology and generation mechanism of each region are preliminarily analyzed.