In order to solve the problem that the theory of gear generation experiment teaching is independent of the engineering practice, the teaching and research group of the mechanical principle of Tsinghua University carried out a systematic teaching reform and design, established the idea and content of comprehensive practice reform for gear design and processing, and constructed the whole process practice method. The basic knowledge of gear design and calculation and theoretical processing method were mastered by using the generating method, and the gear design and simulation and innovative processing method were mastered by introducing the virtual simulation technology. The establishment of the experimental teaching system was conducive to the cultivation of students’ comprehensive ability in the whole process from theoretical design to three-dimensional modeling and simulation, and then to solid processing. It was also conducive to the cultivation of students’ ability of scientific and technological innovation and practical innovation in the future.