Two-dimensional transition metal sulfides are emerging materials with a variety of unique properties, such as maximum electrostatic efficiency, superior mechanical strength, tunable electronic structure, excellent optical transparency, and sensor sensitivity, and are considered potential, ubiquitous electronic, energy, and sensor devices This paper reviews the applications and research progress of Two-dimensional transition metal sulfides in the fields of electrochemical sensors, photochemical sensors, and biosensors,and describes the optimization of their catalytic activities by designing and modulating the positions of metal sulfide energy bands and performing atomic doping, etc, so as to make them more excellent in sensitivity and thus expand their application fields Meanwhile, the development status and advantages of SERS technology in conjunction with the now popular nanozymatic catalytic technology are discussed Finally, the challenges and prospects for the development of 2D transition metal sulfides in sensor technology are envisaged