Co-base self-fluxing alloy was deposited on helical land as cutting lip of end mill which body was made of 45# steel by laser cladding with synchronous feeder. The effect of laser cladding processing parameters on shape and crack of coating was studied, it showed that width of cladding was decided by the effective size of laser beam, which was depended on the power density and the scanning speed. Height of cladding was decided by the ratio of powder feeding rate to the scanning speed, higher laser power can significant reduce crack, and thin cladding shape was valuable to lower the tendency of cladding crack. The special equipment and processing were researched for laser cladding manufacturing end mill. With optimizing parameters using laser cladding technology, functional layers meeting the specification have been achieved on end milling body made of 45# steel. The coating were with crackless, good shape and satisfying hardness, passed cutting test with GB/T122.4.3-90 standard.