Objective: To investigate the clinical efficacy of Nd:YAG laser combined with Er:YAG laser as an adjunctive therapy on generalized aggressive periodontitis (GAgP). Methods: Twelve patients with generalized aggressive periodontitis were randomly assigned into 2 groups, the control group (subgingival scalling+ SRP) and the experimental group (subgingival scalling+ SRP+ laser). Clinical examination of patients with pre-treatment, 1 month, 3 months after treatment, the clinical parameters including probing depth (PD) and bleeding index (BI) were measured.Results: PD and BI in the experimental group were lower than those in the control group at 1 month and 3 months after treatment (P＜0.05).Conclusion: Nd:YAG laser combined with Er:YAG laser as an adjunctive therapy on subgingival scalling + SRP for the treatment of generalized aggressive periodontitis can achieve better curative effect than the simple subgingival scalling+ SRP.