The large numerical aperture and high resolution mobile phone lens using the plastic asphere lenses E48R and LEXANH is demanded with the development of mobile phone market. A kind of large numerical aperture and high resolution mobile phone lens was designed by using Code-v optical design software. The mobile phone lens is constituted by five plastic asphere lenses, an infrared cut filter, and a sensor cover glass. The first and fourth lenses are positive lenses. The second, third, and fifth lenses are negative lenses. Design results show that when the space frequency is 350lp/mm, the modulation transfer function (MTF) of all field of view are more than 0.2, and the MTF of 0.7 field of view are more than 0.34. The field curves are less than 0.02mm, and the distortion are less than 2.55%. It provides a reference value for similar systems.