Pine wilt disease is a forest ailment caused by Bursaphelenchus xylophilus. The current damage status of pine wilt disease was investigated in the Huanggang region of Hubei Province, the reasons behind this situation and areas requiring improvement were analyzed, and comprehensive control measures were proposesd. From 2020 to 2024, the prevention and control situation of pine wilt disease in the study area exhibited fluctuating and recurring characteristics. Its repeated occurrence is associated with climatic change, resistance of pine trees, pesticide resistance of vector insects, and the pine tree community structure. The control process of pine wood nematodes faces several challenges, including the need to enhance public awareness, improve monitoring and regulatory systems, optimize prevention mechanisms, and strengthen the integration of “prevention” and “control”. Based on these findings, comprehensive prevention and control measures are proposed. Specific measures include disseminating knowledge about Bursaphelenchus xylophilus to the public through methods such as installing informational signs, distributing brochures, and utilizing platforms like WeChat official accounts to raise awareness. An immediate and accurate detection and early warning system will be constructed by integrating remote sensing imagery with ground survey data. The “pine protection” campaign will be implemented to improve traceability management mechanisms, while the establishment of a robust quarantine and system for infected wood will be achieved through measures like of infested trees. A cross-regional coordination mechanism will be established to share epidemic data and create a joint prevention and control management system. Strengthening “treatment” will involve the use of biological control (using natural enemy insects like Dastarcus helophoroides and Sclerodermus spp.), physical control (setting up traps), and chemical control methods (such as trunk injection and drone spraying). Efforts to “modify” will be enhanced through forest management practices, such as regulating stand density and increasing green coverage. This article provides a reference for the prevention and control of pine wood nematode disease.