World Clinical Drugs, Volume. 46, Issue 7, 687(2025)

The influence of ultrashort wave and semiconductor laser combined with celecoxib on knee joint function, plantar pressure and blood viscosity in patients with knee osteoarthritis

ZHANG Yan, LIU Wei, and ZHANG Xuesong
Author Affiliations
  • Department of Rehabilitation, the Second Hospital of Tangshan, Tangshan 063000, Hebei Province, China
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    ObjectiveTo investigate the effects of ultrashort wave and semiconductor laser combined with celecoxib on knee joint function, plantar pressure, and blood viscosity in patients with knee osteoarthritis (KOA).MethodsA total of 168 KOA patients admitted to our hospital from September 2021 to September 2023 were selected and divided into three groups based on different treatment therapy methods: celecoxib group (group A, n=56), ultrashort wave and semiconductor laser group (group B, n=53), and ultrashort wave and semiconductor laser combined with celecoxib group (group C, n=59). All groups received continuous treatment for 5 weeks. One month after the treatment, a follow-up was conducted to evaluate changes in knee joint function, VAS pain scores, blood viscosity indicators, plantar pressure, and adverse reactions in the three groups.ResultsAll participants completed the follow-up. After treatment and at 1-month follow-up, the knee joint function and pain reduction of all three groups showed significant improvements compared to those before treatment (P<0.05). After treatment and 1-month follow-up, group C demonstrated superior plantar pressure values in the first toe region, second to fifth toe regions, mid-foot region, and heel region compared to groups A and B, with statistically significant differences(P<0.05). The adverse reaction rate in group C was 5.08%, slightly lower than group A (5.36%) and group B(9.43%), but the difference was not statistically significant (P>0.05).ConclusionCombination therapy with ultrashort wave and semiconductor laser and celecoxib significantly improves blood rheology, promotes knee joint functional recovery, regulates plantar pressure, effectively alleviates pain, and does not increase the risk of adverse events in KOA patients.

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    ZHANG Yan, LIU Wei, ZHANG Xuesong. The influence of ultrashort wave and semiconductor laser combined with celecoxib on knee joint function, plantar pressure and blood viscosity in patients with knee osteoarthritis[J]. World Clinical Drugs, 2025, 46(7): 687

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    Paper Information

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    Received: May. 21, 2024

    Accepted: Aug. 26, 2025

    Published Online: Aug. 26, 2025

    The Author Email:

    DOI:10.13683/j.wph.2025.07.010

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