The Journal of Light Scattering, Volume. 37, Issue 2, 249(2025)
Optical Attenuation-Based Multi-modal OCT Imaging for Thyroid Cancer Recognition
Analyzing the light attenuation and morphological features in optical coherence tomography (OCT) images can improve the diagnostic accuracy of papillary thyroid carcinoma (PTC) tissue. We propose the PDC-DRE attenuation coefficient depth-resolved model, which effectively resolves the systemic overestimation caused by discretization in conventional approaches. The optical attenuation coefficient (OAC=(3.08±0.64) mm-1) of PTC tissues is significantly lower than that of normal thyroid tissues (OAC=(4.47±0.85) mm-1). A multi-modal image dataset was established by integrating optical attenuation features with OCT morphological imaging, and a custom ThyOCTNet model was employed to differentiate between normal and PTC tissues. Results demonstrate that the ThyOCTNet model achieves enhanced sensitivity (98.5%), specificity (98.8%), and accuracy (98.6%) with multi-modal images compared to single-modal images. This study confirms that OCT multi-modal fusion imaging combining optical attenuation and morphological features significantly improves PTC identification accuracy, providing a new technical pathway for the clinical translation of non-invasive pathological diagnostic technologies.
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HE Xiang, ZHAO Chao, DING Xiaodong, LI Jiefu, YU Chenglong, MA Jun. Optical Attenuation-Based Multi-modal OCT Imaging for Thyroid Cancer Recognition[J]. The Journal of Light Scattering, 2025, 37(2): 249
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Received: Mar. 14, 2025
Accepted: Jul. 31, 2025
Published Online: Jul. 31, 2025
The Author Email: MA Jun (majun@ouc.edu.cn)