In order to solve the problem that the monochromatic aberration of the electrowetting liquid lens focusing system changes greatly with the focusing process, a design scheme of correcting the monochromatic aberration of the system by using liquid crystal lens with adjustable gradient refractive index distribution is proposed. At 850 nm wavelength, liquid crystal lens is used to correct the monochromatic images of the system at six typical object distances ranging from infinity to 200 mm. At the infinite object distance with the largest aberration, the geometric radius of the dot pattern of the edge field of view is reduced from 44.696 μm to 7.423 μm, and the speckle in other fields is reduced to the Airy spot. And the monochromatic aberration of the system has been corrected. In order to reduce the response time of the liquid crystal lens, the liquid crystal lens is replaced by laminated combination of five liquid crystal lenses with 1 / 5 cell thick, which enhances the response speed significantly. It has been found that this structure also has a favorable correction effect on the monochromatic aberration of the system at different object distances.