When high-speed imaging guidance missile was flying in the atmosphere, which was affected by aero-optical effect, and then the imaging target position was different from the actual position. It was difficult for aero-optical imaging deviation to be corrected, due to the very strong random and nonlinear characteristic. The deviation of light rays passing through a variable refractive index field was measured based on Background Oriented Schlieren (BOS), the control points between the distortion image and reference image (undistorted image) were built, local weighted mean fitting method was adopted to construct the mapping function for the image correction, and bi-cubic convolution method was used to resample the image gray value, the distortion images were corrected at last. The imaging deviations caused by the stationary phase (lens) and the jet Mach number 3.0 supersonic film were corrected partly, and the validity of the correction method is confirmed by the experimental results.