ObjectiveTo explore the clinical relationship between the expression of long intergenic non-coding ribonucleic acid (LINC) 01503 in breast cancer tissue and postoperative recurrence and metastasis.MethodsThree hundred and ninety-two patients with breast cancer in the First Affiliated Hospital of Zhengzhou University from January 2020 to August 2023 were selected for surgical treatment. Samples of surgically resected cancer tissues and adjacent tissues were collected, the relative expression of LINC01503 were detected by real-time fluorescence quantitative polymerase chain reaction (RT-qPCR). The relative expressions of LINC01503 in breast cancer tissues with different clinicopathological features were compared. All patients were followed up until March 2024 or postoperative recurrence and metastasis. According to the following up results, they were divided into recurrence and metastasis group and no recurrence and metastasis group. The clinical data and relative expression of LINC01503 in cancer tissues were compared between the 2 groups, the influencing factors of postoperative recurrence and metastasis were analyzed by Cox regression method, and the hazard ratio (HR) and 95% confidence interval (95% CI) were calculated.ResultsThree hundred and eighty-four cases were included after the cases were excluded. The relative expression of LINC01503 in breast cancer tissues was 3.35±0.72, which was higher than that in paracancer tissues (1.00) (P<0.05). The relative expression of LINC01503 in cancer tissues of patients with carcinoma in situ was lower than that of other pathological type (P<0.05). The relative expression of LINC01503 in cancer tissues of patients with triple negative, tumor-node-metastasis (TNM) stage Ⅲ/Ⅳ, low/undifferentiated tumor, vascular cancer thrombus, nerve invasion and highly microsatellite instability were higher than those of other molecular subtypes, TNM stage Ⅰ/Ⅱ, medium/highly differentiated tumor, no vascular cancer thrombus, no nerve invasion and no highly microsatellite instability (P<0.05). The following up period was 5-49 months, median 32 (16, 42) months. The recurrence and metastasis rate was 18.49% (71/384). Molecular subtypes triple negative (HR=2.633, 95% CI: 1.607－4.314), TNM stage Ⅲ/Ⅳ (HR=2.892, 95% CI: 1.560－5.362), low/undifferentiated tumors (HR=3.165, 95% CI: 1.538－6.510), vascular cancer thrombus (HR=2.667, 95% CI: 1.660－4.286), nerve invasion (HR=2.192, 95% CI: 1.505－3.194), highly microsatellite instability (HR=2.002, 95% CI: 1.420－2.821), carbohydrate antigen (CA) 125 (HR=2.121, 95% CI: 1.467－3.066) and relative expression of LINC01503 in cancer tissues (HR=3.083, 95% CI: 1.637－5.807) were independent risk factors for postoperative recurrence and metastasis (P<0.05).ConclusionThe relative expression of LINC01503 in cancer tissues of breast cancer patients is increased, and it is not only related to pathological type, molecular subtype, TNM stage, tumor differentiation degree, vascular cancer thrombus, nerve invasion and highly microsatellite instability, but also a risk factor for postoperative recurrence and metastasis.