Objective: Evaluating the efficacy and safety of intense pulsed light (IPL) and red light combined with tacrolimus ointment in the treatment of facial seborrheic dermatitis (SD). Methods: 201 patients with facial SD were randomly divided into experimental group A, B, C and control group. Control group was treated with tacrolimus ointment, experimental group C, B, and A were treated with red light, IPL, red light and IPL on the basis of the former. The course of treatment was 8 weeks. The therapeutic effect and the adverse reactions were evaluated after the treatment. Rseults: The symptoms and signs were significantly improved after treatment with IPL and red light (P＜0.05). Experimental group B inhibited seborrhea and experimental group A improved the skin lesion area and pruritus more obviously. There was no significant difference in the improvement degree of erythema (P>0.05).There was statistically significant difference in effective rate among the four groups (P<0.05).After combined treatment, cuticle moisture content, transepidermal water loss and quality of life were improved, and patient satisfaction was higher. There were no serious adverse reactions in the four groups. Conclusion: IPL and red light combined with tacrolimus ointment are safe and effective in the treatment of facial SD.