To address the challenges of increased production space, equipment transportation and installation costs caused by the excessive volume and mass of forging hydraulic press centering devices, this study focuses on the lightweight design of an 80MN forging hydraulic press centering device. A 3D model of the centering device was developed using SolidWorks, and static analysis was performed with ANSYS Workbench finite element software based on its actual stress conditions. Four design variables were selected for optimization using the response surface methodology. A mathematical model was established with minimum total mass as the objective function, constrained by maximum deformation and equivalent stress. Static reanalysis of candidate points demonstrated that optimized results met deformation and stress requirements while achieving a 1 284 kg mass reduction. The lightweight design effectively reduces device weight, improves material utilization, and enhances overall production efficiency while maintaining required strength and stiffness.