This design develops a smart medication box based on a microcontroller control system，completing both hardware and software development. On the hardware side，it integrates functional modules including buttons，a real-time clock，an LCD display，indicator lights，limit switches，Bluetooth communication，temperature/humidity detection，voice prompts，and a buzzer. The circuit design of each module ensures accurate connectivity with the microcontroller pins. For software implementation，the control program was developed according to predefined logic and functional requirements，with system validation performed using simulation and debugging tools. Test results demonstrate that the system features user-friendly operation，rapid response，and effectively improves medication adherence while ensuring user safety.