To develop a high performance biomedical dry electrode, the laser micromilling-recasting technology is used to fabricate the metal dry electrode with surface micostructure arrays. Based on the analysis of the micro morphology of the electrode surface, the wettability of the electrode surface is discussed, and then the influence of laser processing parameters such as scanning spacing, scanning speed and scan times on the adhesion per-formance of Escherichia coli is further investigated. The results show that the contact angle of metal dry electrode with surface microstructure arrays fabricated with reasonable laser processing parameter can reach more than 150° and show the superhydrophobic characteristics. The adhesion performance of escherichia coli of electrode is changed greatly with different scanning spacing and scan times. When the 0.1 mm scanning spacing is se-lected, the least amount of escherichia coli is found on the surface of electrode. With the increasing scan times, the adhesion amount of escherichia coli can be reduced. However, the scanned speed has little effect on the adhesion performance of escherichia coli for metal dry electrode.