To investigate the influence of laser processing parameters on the structural parameters of microstructures on the surface of cemented carbide, a nanosecond laser was employed to create grooved microstructures on YG8 cemented carbide. A one-factor test was conducted to analyze the variation in groove width and depth under different laser parameters. The results of one-factor test show that: the groove width and depth with the laser parameters of the law of change is consistent, both increase with the increase in scanning power, decrease with the increase in laser repetition frequency, decrease with the increase in scanning speed, increase with the increase in scanning times. In addition, the laser repetition frequency has a greater impact on the width of the groove than on the depth of the groove; the scanning power, scanning speed, and scanning times have a greater impact on the depth of the groove than on the width of the groove.