Cell Research, Volume. 35, Issue 8, 545(2025)

New insights into how parental worms protect their offspring

Zeng Chenming and Miska Eric A.

Parental exposure of Caenorhabditis elegans to pathogens can protect offspring against similar threats, but the bacterial cues and intergenerational signals underlying this response remain poorly understood. A recent study in Cell revealed a novel mechanism of intergenerational protection against natural pathogens, facilitated by the cyanoalanine synthase CYSL-2 and its detoxification intermediate.

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Zeng Chenming, Miska Eric A.. New insights into how parental worms protect their offspring[J]. Cell Research, 2025, 35(8): 545

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Paper Information

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Received: --

Accepted: Aug. 26, 2025

Published Online: Aug. 26, 2025

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DOI:10.1038/s41422-025-01094-8

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