The laser cladding technology is used to clad Fe-W-B ternary boride cladding layer on 65Mn steel surface. Through the experiments of single-pass cladding and single-layer multi-channel cladding, the effects of laser power, scanning speed, powder feeding rate and lap rate on the quality of cladding layer are explored to obtain the optimal combination of laser process parameters. The cladding layer is analyzed by optical microscope, X-ray diffractometer and Vickers hardness tester. The results show that the influence of process parameters on the height of the molten pool and the width of the molten pool are in descending order: powder feeding rate, scanning speed and laser power, and the influence on Vickers hardness is in descending order: scanning speed, powder feeding rate and laser power. The optimal combination of process parameters is obtained as follows: laser power of 800 W, scanning speed of 3 mm/s, powder feeding rate of 4 g/min, lap rate of 50%. The average Vickers hardness of the cladding layer is 757.9 HV, which is 3.5 times that of the substrate. The cladding layer is well combined with the metallurgy of the substrate, and its microstructure consists of dendritic crystals, cytocrystals and columnar crystals.