To investigate the expression of GSDMB and GSDMD in skin cutaneous melanoma (SKCM) and their correla-tion with prognosis and immune infiltration based on bioinformatics. The expression and variation of GSDMB and GSDMD in SKCM were analyzed by GEPIA2 database and cBioportal database. The prognostic value of GSDMB and GSDMD on SKCM was analyzed by GEPIA2 database. The GSCA database was used to analyze the correlation between the expression level of GSDMB and GSDMD in SKCM and the activity of tumor-related pathways. The TIMER database was used to analyze the rela-tionship between the expression level of GSDMB and GSDMD in SKCM and the infiltration level of immune cells. The results showed that the expression level of GSDMB in SKCM tissue was significantly lower than that in normal tissue, while the ex-pression level of GSDMD was significantly higher than that in normal tissue. In 363 SKCM samples, the total variation rate of GSDMB and GSDMD was 9.64%, with mutations predominating (4.96%). The high expression level of GSDMB and GSDMD was significantly associated with the higher overall survival rate of SKCM patients. GSDMB may activate apoptosis pathway in