In order to mitigate the impact of micro-vibration on the performance of the multi-load integrated small satellite, the paper proposes a satellite vibration isolation scheme and establishes an integrated analysis model for multi-load micro-vibration to evaluate the suppression effect. First, a two-stage passive isolation scheme from the vibration source to the load is designed. Second, the relationship between image shifts is established for the linear optical system and the optical element motion, and then the micro-vibration integrated analysis model with different optical loads is established to account for the difference of sensitivities of optical loads to micro-vibration. The comprehensive image shifts before and after the satellite vibration isolation are calculated. Finally, both the micro-vibration measurement test on the ground and the push-scan imaging verification in orbit are carried out. The results show that the maximum integrated image shift calculated by the integrated model is less than 0.25 pixels, the maximum peak-to-peak vibration values for the laser and camera's primary mirror in the ground test are 0.05″ and 0.012″, respectively, and the maximum image shift value in the frequency domain for the in-orbit imaging optical camera is 0.061 pixels. Both the ground and in-orbit micro-vibration measurement data validate the effectiveness of the vibration isolation system design and the integrated analysis model.