The excessive use of organophosphorus compounds has led to severe environmental pollution. Studies have shown that even at residual concentrations exceedingly below current safety thresholds, these compounds can still induce various neurological disorders, posing long-term threats to human health. It is imperative to develop chemical sensors with high sensitivity, high selectivity, and rapid response. In this study, the sensing selectivity of the material to the analyte is enhanced via molecular design. Furthermore, the material interface with a high specific surface area is obtained via in-situ electrochemical polymerization, improving the sensing sensitivity. Based on kinetic fitting calculations, the sensing conditions are optimized, significantly increasing the sensing response rate and endowing it with reusability. Eventually, an organophosphorus mass sensing that satisfies the detection limit at the 10^-9 level and has strong anti-interference ability is realized on a quartz crystal microbalance, while also considering the response speed at the second level and reusability.