APPLIED LASER, Volume. 42, Issue 6, 149(2022)
Clinical Observation on Modified Jingfangfang Combined with Low-Level Light Therapy with Light-Emitting Diodes for the Treatment of Wind-heat Type Facial Corticosteroid Addictive Dermatitis
To observe the clinical effect of modified Jingfangfang combined with low-level light therapy with light-emitting diodes (LED-LLLT) on wind-heat type Facial Corticosteroid Addictive Dermatitis (FCAD), 83 patients with wind-heat type FCAD were randomly assigned to 41 cases in the treatment group and 42 cases in the control group. Patients in both groups were treated with skin barrier repair agents and 830 nm/ 590 nm LED-LLLT externally, and the treatment group was additionally given modified Jingfangfang internal medication, both for 8 weeks. Pruritus, burning, erythema, pain, tightness and Dermatological Life Quality Index (dermatology life quality index,DLQI) scores at different times before and after treatment were compared, and clinical efficacy of skin barrier function, serum IFN-γ levels and IL-4 levels before and after treatment and evaluation were detected. Results show that 4 weeks after treatment, the total effective rates were 75.61% in the treatment group and 54.76% in the control group. 8 weeks after treatment, the total effective rate of the treatment group was 92.68%, and that of the control group was 76.19%. It demonstrates that the treatment group was better than the control group, and the difference between the two groups was statistically significant (P<0.05). At 2 weeks, 4 weeks, and 8 weeks after treatment, the scores of itching, burning, pain, tightness, and erythema area decreased in both groups (P<0.05). Meanwhile, the scores of pruritus in the treatment group were lower than those in the control group at the same time (P<0.05). At 8 weeks after treatment, the erythema area scores were lower the treatment group than in the control group (P<0.05). DLQI scores of the treatment group were lower than those of the control group at 4 weeks and 8 weeks after treatment (P<0.05). After treatment, TEWL decreased, epidermal water content increased, and stratum corneum thickened in both group, with the treatment group outperforming the control group (P<0.05). IFN-γ levels and IL-4 levels of the treatment group and the control group were significantly different from pre-treatment (P<0.05). Modified Jingfangfang combined with LED-LLLT to treat wind-heat type FCAD can significantly improve the symptoms of patients and the quality of life.
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He Zhihong, Wang Jianfeng, Zhang Hongya. Clinical Observation on Modified Jingfangfang Combined with Low-Level Light Therapy with Light-Emitting Diodes for the Treatment of Wind-heat Type Facial Corticosteroid Addictive Dermatitis[J]. APPLIED LASER, 2022, 42(6): 149
Received: Dec. 24, 2021
Accepted: --
Published Online: Feb. 4, 2023
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