22MnB5 hot-formed steel with aluminum-silicon coating was welded by fiber laser. The effects of different wire feeding speeds on the weld morphology, droplet transition form, microstructure, element content and distribution, and tensile properties were studied. The results showed that the weld formed well and had no obvious defects. The droplet transition is a liquid bridge transition. The weld microstructure after heat treatment at different wire feeding speeds is composed of martensite and δ-ferrite. With the increase of wire feeding speed, the content of Al and δ-ferrite in the weld decreases continuously. With the increase of wire feeding speed, the tensile strength of the joint first increases and then decreases.