First of all, using a carbon dioxide laser with a wavelength of 10.6 μm, the surface of TC4 alloy was polished. The surface roughness of the material was measured with a three-dimensional profile instrument. The influences of factors on the surface roughness such as laser power, defocus amount, scanning speed, and scanning pitch were analyzed in combination with the micro-morphology of the material surface before and after polishing. Obtaining the ideal process parameters, the minimum surface roughness of the TC4 alloy was 117.62 nm. However, thecarbon dioxide laser polishing caused serious heat accumulation and obvious surface cracks. Then, using a fiber laser with a wavelength of 1080 nm polished the TC4 alloy.Similarly, The effects on the surface roughness such as surface morphology, defocus amount, and scanning path were analyzed. Innovatively using multiple moving scanning polishing, theoptimal polishing effect was achieved. The minimum surface roughness of the TC4 alloy was148.91 nm. The experimental results show that the using of the fiber lasers for multiple shifting scans can more quickly and effectively polish the TC4 titanium alloy. And due to the low laser energy density, there is no obvious deformation and cracks on the surface of the TC4 alloy.