The application demand of solid-state lasers continues to grow, and traditional Nd∶YAG lasers are faced with high cost, high power consumption and poor mechanical properties due to the dependence on complex temperature control systems, which need to be solved urgently in order to expand applications. In this paper, an uncooled multi-wavelength VCSEL pumped solid-state laser design scheme is proposed, aiming to achieve high power stable output over a wide temperature region by optimizing multi-wavelength VCSEL combination. A three-wavelength VCSEL array was used as a pump source to side-pump Nd∶YAG crystals with a size of Φ 6 mm×40 mm and a doping concentration of 1.0 at.%. Wavelength complementation of multi-wavelength VCSEL arrays effectively reduces the influence of temperature drift on crystal absorption efficiency. At the same time, the four-sided pump design improves the utilization rate of pump light range and the uniformity of particle number inversion. The experimental results show that the laser can work with high performance at 5~45 ℃, and the output power can still exceed 100 W at 45 ℃. Under the pump current of 80 A and repetition frequency of 20 Hz, the maximum peak power of 3∶2∶1 module reaches 302.8 W, and the overall fluctuation is 17.83%, which is better than that of single-wavelength module. Multi-wavelength modules maintain high stability at extreme temperatures through multi-band compensation mechanism.