Exploring the mechanism of Fangji Huangqi Decoction in the treatment of children with nephrotic syndrome by means of network pharmacology and molecular docking. We systematically searched TCMSP platform to obtain 78 active ingredients and 132 targets of Fangji Huangqi Decoction, and standardized the target name according to the gene name loaded by UniProt database. By searching the OMIM and DisGenet databases, a total of 1 754 targets of pediatric nephrotic syndrome were obtained, after removing the duplicate targets and standardizing target name according to the Uniprot database. Drawing a Venn diagram through Venn online platform was conducted to obtain 48 targets for the common parts of drugs and diseases. Cytoscape software was used to construct a network of target proteins of the active ingredient of Fangji Huangqi Decoction-drug disease. Quercetin, kaempferol, medicarpin, 7-O-methylisomucronulatol, 2-［(3R)-8,8-dimethyl-3,4-dihydro-2H-pyrano ［6,5-f］chromen-3-yl］-5-methoxyphenol were selected as the key active ingredients according to the degree of the network. The drug-disease common targets were imported into the String platform, the protein interaction network was obtained. Cytoscape was used for the protein interaction network topological analysis and sub-module analysis. Through this work, the core targets AKT1, MYC, and TP53 were obtained. The metascape platform was used to perform GO biological processes and KEGG enrichment pathway analysis on the common targets of disease drugs, it was found that the GO biological process is mainly related to blood system, cell stress, regulation of growth, regulation of protein serine/threonine kinase activity, leukocyte differentiation. The result of KEGG pathway is mainly related to the MAKP signaling pathway and the PI3K-Akt signaling pathway. The molecular docking of key targets and key components was carried out by AUTODOCK software, the results were all less than -5.0 kcal/mol. After the analysis, it was found that Fangji Huangqi Decoction for the treatment of pediatric nephrotic syndrome mainly relies on the two signal pathways of MAPK and PI3K-Akt, and acts on MYC, AKT1 target proteins through quercetin, kaempferol, mediterrantol, 7-O-methylisomucronulatol, 2-［(3R)-8,8-dimethyl-3,4-dihydro-2H-pyrano ［6,5-f］chromen-3-yl］-5-methoxyphenoand other active ingredients. Meanwhile, it requires the participation of various biological processes, such as the circulatory system, cell stress, growth regulation, protein serine/threonine kinase activity regulation, leukocyte differentiation, etc, to achieve complex comprehensive regulation with multiple components, multiple targets, multiple levels, and multiple pathways. It provides a reference for the further research and clinical application of Fangji Huangqi Decoction.