Journal of Forensic Medicine, Volume. 41, Issue 2, 120(2025)

Research on Doxorubicin-Induced Cardiotoxicity Mechanism and Its Forensic Application

ZHANG Shuai, XU Hong-fei, ZHANG Zhi-xiang, WANG Ying, and ZHU Shao-hua*
Author Affiliations
  • Department of Forensic Medicine, School of Basic Medical Sciences, Soochow University, Suzhou 215123, Jiangsu Province, China
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    Doxorubicin is a commonly used antitumor drug for the treatment of various cancers. However, its clinical application is greatly restricted by its severe cardiotoxicity. At present, doxorubicin-induced cardiotoxicity is categorized into acute and chronic forms, depending on the dosage and duration of exposure, which may eventually lead to the occurrence of heart failure. The pathogenesis of doxorubicin cardiotoxicity is associated with oxidative stress, mitochondrial damage, calcium overload, dysregulation of autophagy, and apoptosis. In forensic medical practice, cases of poisoning or even cardiac death caused by doxorubicin showed no obvious changes in cardiac morphology through routine forensic pathological examinations. The paper aims to summarize the research on the mechanisms of action of doxorubicin-induced cardiotoxicity in recent years, analyze and discuss the possible pathways of cardiomyocyte injury caused by doxorubicin, and provide references for research on the mechanisms of doxorubicin-induced cardiotoxicity and forensic application.

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    ZHANG Shuai, XU Hong-fei, ZHANG Zhi-xiang, WANG Ying, ZHU Shao-hua. Research on Doxorubicin-Induced Cardiotoxicity Mechanism and Its Forensic Application[J]. Journal of Forensic Medicine, 2025, 41(2): 120

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    Paper Information

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    Received: Apr. 12, 2024

    Accepted: Aug. 25, 2025

    Published Online: Aug. 25, 2025

    The Author Email: ZHU Shao-hua (zhushaohua@suda.edu.cn)

    DOI:10.12116/j.issn.1004-5619.2024.440404

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