WMoTaNb refractory high-entropy alloy coating was prepared on the surface of GH4169 alloy by laser cladding in this paper. The optimal combination of process parameters was determined by regulating two process parameters, namely, laser power and scanning speed. Then SEM, XRD, EDS, microhardness tester and friction and wear tester were used to characterize the microstructure, phase structure, element distribution, hardness and tribological properties of the coating. The results show that the coating is mainly composed of columnar crystals and disordered dendrites, and the main phase structures are BCC phase and Fe-containing phase. There is a mutual dilution and diffusion of elements between the coating and the substrate, forming a relatively good bond. The microhardness of the WMoTaNb coating prepared by laser cladding can reach 1 007.5 HV, and the wear rate at room temperature is only 5.49×10-5 mm3/(N·m), which is far better than the GH4169 alloy matrix. These excellent performances provide more potential possibilities for the performance enhancement and engineering applications of GH4169 alloy.