Fe-S/TiO₂/GFC photocatalyst co-doped with Fe and S was prepared by sol-gel method and dip coating method with TiO₂ as photocatalyst and glass fiber cloth (GFC) as carrier material. SEM, XRD, XPS, UV vis and other methods were used to analyze and characterize it. The results of the single factor experiment showed that when the initial pH value, light intensity, initial concentration of ibuprofen, and catalyst dosage of the ibuprofen solution were 5, 54 000 lux, 10 mg/L, and 0.15 g, respectively, the degradation rate of ibuprofen was the highest, at 80.7%, 80.71%, 81.64% and 82.11%, respectively. Through response surface modeling analysis, the optimal conditions for ibuprofen degradation were determined to be a pH of 5.4 for the ibuprofen solution, an initial concentration of 10.31 mg/L for the ibuprofen solution, and a catalyst dosage of 0.15 g. At this point, the ibuprofen degradation rate was 80.04%. The verification experiment found that the difference between the optimized actual response value and the predicted response value was about 0.5%, indicating that the response surface model has good fitting and reliability. Common cations in natural water bodies such as Na⁺, K⁺, Ca²⁺ and Mg²⁺ have almost no effect on the degradation process of ibuprofen. Common anions such as Cl^- and HCO₃^- have a significant inhibitory effect on the degradation of ibuprofen, while SO₄^2- has little effect. NO₃^- promotes the degradation of ibuprofen.