Ni-60%WC coatings were prepared on 45 steel via the laser cladding process, employing various laser power settings. The microstructure of obtained coatings was analyzed using a super depth of field microscope. The effect of laser power on the tribological performance of Ni 60%WC coating was investigated using a wear tester, and the wear mechanism was discussed by the wear model. The results show that the average coefficients of friction of Ni 60% WC coating at the laser power of 1 400, 1 700, 2 000 and 2 300 W are 0.291, 0.375, 0.338, and 0.261, respectively, and the corresponding wear rates are 26.48, 21.44, 30.24, and 27.36 μm3/(N·mm), respectively. The wear rate of Ni 60%WC coating at the laser power of 1 700 W decrease by 19%, 29%, and 22% compared with those at the laser power of 1 400, 2 000 and 2 300 W, respectively, which indicates that the appropriate laser power may improve its wear resistance. Furthermore, laser power exhibited negligible influence on the wear mechanism of Ni 60%WC coatings, with abrasive wear and adhesive wear identified as the primary modes of degradation.