Slanted-edge imaging quality analysis method is one of the most commonly used methods in the evaluation of modulation transfer function(MTF). This imaging process method has broad application prospect because of its high beam transmission energy and strong practicability. The application of slanted-edge imaging quality analysis method to the camera imaging quality evaluation system under laser irradiation is credible and effective. However, the factors such as edge inclination angle, gray contrast on both sides of edge and background noise should be considered comprehensively. The MTF curves and modulation transfer function amplitude (MTFA) values of the system under different power densities and spot positions are calculated by the slanted-edge imaging quality analysis method. The results indicate that when the laser power density is low or the spot position is far from the edge, the influences of the edge contrast and the MTF value are weak. With the increase of laser power density or the spot position is close to the edge, the local MTF value decreases, the influences of the edge contrast and the MTF value gradually increase, and the interference effect is obvious gradually. Especially when the spot covers the target, the MTF value cannot be calculated, and the interference effect is the best. Therefore, the imaging quality of optical cameras can be evaluated qualitatively and quantitatively based on the slanted-edge imaging quality analysis method. Based on the simulation results, establishment of an imaging quality evaluation system of optical camera under laser irradiation can provide technical support for laser irradiation effect experiment and laser jamming effect evaluation of optical camera.